Fibrin and Extracellular Matrix: Scaffolds and Network for Malignant Cells

Malignant cells build up a protective shield in form of fibrin meshwork surrounding the tumor which helps it to escape body’s immune system. In addition, and stromal provide with an abundant extracellular matrix (ECM) consisting proteoglycans, collagens, glycoproteins glucosaminoglycans additional scaffold capacity bind large quantities immunsuppressive substances. Many investigations found that heparin has wide variety positive effects counteracting these shielding immunosuppressive properties ECM. Heparin can neutralize many substances produced by cells. It inhibits cross-linking collagen deamination, reduces expression FAK, LOX, glucosamines proteoglycans. By actions prevents development stiff rigid ECM presents additionally effective for also reduce efficiency therapeutic methods. ambulant trial exogenously-added high dosages survival probability over three years was significantly higher than without (p<0.001). Therefore, combined therapy fibrinolyticum should be considered. This auxiliary treatment potential support established improve anti-tumor response